2018 年論文研究成果

  1. Chiang CS, Lin YJ, Lee R, Lai YH, ChengHW, Hsieh CH, Shyu WC*, Chen SY. Combination of fucoidan-based magnetic nanoparticles and immunomodulators enhances tumour-localized immunotherapy. Nature Nanotechnology 2018;13:746-754.

  2. Lee PC, Fang YF, Yamaguchi H, Wang WJ, Chen TC, Hong X, Ke B, Xia X, Wei Y, Zha Z, Wang Y, Kuo HP, Wang CW, Tu CY, Chen CH, Huang WC, Chiang SF, Nie L, Hou J, Chen CT, Huo L, Yang WH, Deng R, Nakai K, Hsu YH, Chang SS, Chiu TJ, Tang J, Chang SJ, Zhang R, Wang L, Fang B, Chen T, Wong KK, Hsu JL and Hung MC*. Targeting PKCδ as a therapeutic strategy against the heterogeneity of EGFR inhibitor resistance in EGFR-mutant lung cancer. Cancer Cell 34(6):954-969, 2018.

  3. Dou C¥, Liu Z¥, Tu .¥, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH* and Kang N.* P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-promoting Myofibroblasts. Gastroenterology 154(8):2209-2221, 2018.

  4. WC-Shen, YH-Chou, HP-Huang, JF-Sheen, SC-Hung, HF-Chen. Induced pluripotent stem cell-derived endothelial progenitor cells attenuate ischemic acute kidney injury and cardiac dysfunction. Stem Cell Res Ther. 9(1):344, 2018.

  5. TY-Kuo, CM-Lin, SC-Hung, TY-Hsien, DM-Wang, HJ-Hsieh. Incorporation and selective removal of space-forming nanofibers to enhance the permeability of cytocompatible nanofiber membranes for better cell growth. Journal of the Taiwan Institute of Chemical Engineers. 91:146–154, 2018.

  6. JP-Wang, HM-Yu, ER-Chiang, JY-Wang, PH-Chou, SC-Hung. Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-β1 (TGF-β1). PLoS One. 13:e0198326, 2018.

  7. CH-Ho, CW-LaN, CY-Liao, SC-Hung, HY-Li, YJ-Sung. Mesenchymal stem cells and their conditioned medium can enhance the repair of uterine defects in a rat model. J Chin Med Assoc. 81(3):268-276, 2018.

  8. CC-Liu, Jhan-Lin, TW-Hsu, JW-Chang, Kelly Su, HS-Hsu, SC-Hung*. Collagen XVII/Laminin-5 Activates Epithelia-to-Mesenchymal Transition and is Associated with Poor Prognosis in Lung Cancer. Oncotarget, 9(2):1656-1672, 2018.

  9. Chen YL, Hu CM, Hsu JT, Chang CC, Huang TY, Chiang PH, Chen WY, Chang YT, Chang MC, Tien YW, Lee EY, Jeng YM, Lee WH*, 2018, “Cellular 5-hydroxylmethylcytosine content determines tumorigenic potential and prognosis of pancreatic ductal adenocarcinoma.”, American Journal of Cancer Research, 8(12), 2548-2563.

  10. Son HG, Seo K, Seo M, Park S, Ham S, An SWA, Choi ES, Lee Y, Baek H, Kim E, Ryu Y, Ha CM, Hsu AL, Roh TY, Jang SK, Lee SJ: Prefoldin 6 mediates longevity response from heat shock factor 1 to FOXO in C. elegans (2018) Genes and Development. 32(23-24): 1562-1575.

  11. HL-Wang, EY-Kuo, TW-Lai*. Vascular delivery of intraperitoneal Evans blue dye into the blood-brain barrier-intact and disrupted rat brains. NeuroReport. 29(11): 924-931, 2018.

  12. Kao, S.H., Wu, H.T., and Wu, K.J.* Ubiquitination by Huwe1 in tumorigenesis and beyond. J. Biomedical Sciences, 25, 67, 2018. (invited review).

  13. Huang, L.C., Tam, K.W., Liu, W.N., Lin, C.Y., Hsu, K.W., Hsieh, W.S., Chi, W.M., Lee, A.W., Yang, J.M., Lin, C.L., and Lee, C.H. (2018) CRISPR/Cas9 genome editing of epidermal growth factor receptor sufficiently abolished oncogenicity in anaplastic thyroid cancer. Disease Markers, 2018, 3835783.

  14. Hsu, K.W., Huang, C.Y., Tam, K.W., Lin, C.Y., Huang, L.C., Lin, C.L., Hsieh, W.S., Chi, W.M., Chang, Y.J., Wei, P.L., Chen, S.T., and Lee, C.H. (2018) The application of non-invasive apoptosis detection sensor (NIADS) on histone deacetylation inhibitor (HDACi)-induced breast cancer cell death. Int. J. Mol. Sci., 19, E452.

  15. Lin, Z.-S., Chung, C.-C., Liu, Y.-C., Chen, T.-M., Yu, Y.-L., Wang, S.-C., Chen, Y.-H. FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression. American Journal of Cancer Research, 8: 1989-2004, 2018.

  16. Lin ZS, Chung CC, Liu YC, Chen TM, Yu YL, Wang SC and Chen YH*. FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression. Am J Cancer Res 8(10):1989-2004, 2018.

  17. Huang SP, Chiou J, Jan YH, Lai TC, Yu YL*, Hsiao M* and Lin YF*. Over-expression of lysyl oxidase is associated with poor prognosis and response to therapy of patients with lower grade gliomas. Biochem Biophys Res Commun 501(3):619-627, 2018.

  18. Wu TK, Liu HC, Lin SY, Yu YL* and Wei CW.* Extracts from guava fruit protect renal tubular endothelial cells against acetaminophen‑induced cytotoxicity. Mol Med Rep 17(4):5544-5551, 2018.

  19. Chien YC, Liu LC, Ye HY, Wu JY and Yu YL*. EZH2 promotes migration and invasion of triple-negative breast cancer cells via regulating TIMP2-MMP-2/-9 pathway. Am J Cancer Res 8(3):422-434, 2018.

  20. Chang LC*, Chiang SK, Chen SE, Yu YL, Chou RH and Chang WC Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis. Cancer Lett 416(2018):124-137, 2018.

  21. Wu TK, Pan YR, Wang HF, Wei CW* and Yu YL*. Vitamin E (α‑tocopherol) ameliorates aristolochic acid‑induced renal tubular epithelial cell death by attenuating oxidative stress and caspase‑3 activation. Mol Med Rep 17(1):31-36, 2018.

  22. Tu CY, Wang BW, Cheng FJ, Chen CH, Hsia TC, Wei YL, Chen CY, Hsieh IS, Yeh YL, Wang LY, Chen CM, Chang WC* and Huang WC*. Incense burning smoke sensitizes lung cancer cells to EGFR TKI by inducing AREG expression. Am J Cancer Res 8(12):2575-2589, 2018.

  23. Tu CY, Cheng FJ, Chen CM, Wang SL, Hsiao YC, Chen CH, Hsia TC, He YH, Wang BW, Hsieh IS, Yeh YL, Tang CH, Chen YJ and Huang WC*. Cigarette smoke enhances oncogene addiction to c-MET and desensitizes EGFR-expressing non-small cell lung cancer to EGFR TKIs. Mol Oncol 12(5):705-723, 2018.

  24. Fan HC, Chen CY, Hsu YC, Chou RH, Teng CJ, Chiu CH, Hsu CY, Muo CH, Chang MY and Chang KH*. Increased risk of incident nasopharyngeal carcinoma with exposure to air pollution. PLoS One 13(9):e0204568, 2018.

  25. Chou RH, Lee CY, Chong LW, Chang KH, Lin CL, Yan KS, Tsou C and Hsu YC*. HBV infection increases the risk of macular  degeneration: the roles of HBx-mediated sensitization of retinal pigment epithelial cells to UV and blue light irradiation. J Transl Med 16(1):221, 2018.

  26. Peng CM, Liu HC, Hsieh CL, Yang YK, Cheng TC, Chou RH* and Liu YJ*. Application of a commercial single-port device for robotic single-incision distal pancreatectomy: initial experience. Surg Today 48(7):680-686, 2018.

  27. Chong LW, Hsu CC, Lee CY, Chou RH, Lin CL, Chang KH and Hsu YC*. Association of viral hepatitis and bipolar disorder: a nationwide population-based study. J Transl Med 16(1):173, 2018.

  28. Chiang YY, Tsou CF*, Chen BC and Chou RH. Glass-based microchip with finger electrodes for the formation, collection, and biointeractions of liposomes. J Micro/Nanolith MEMs MOEMS 17(2):025001, 2018.

  29. Chang LC*, Chiang SK, Chen SE, Yu YLh, Cou RH and Chang WC Heme oxygenase-1 mediates BAY 11-7085 induced ferroptosis. Cancer Lett 416(2018):124-137, 2018.

  30. Khan MI, Su YK, Zou J, Yang LW, Chou RH* and Yu C.* S100B as an antagonist to block the interaction between S100A1 and the RAGE V domain. PLoS One 13(2):e0190545, 2018.

  31. Hsu PY, Lin WY, Lin RT, Juo SH*. MicroRNA let-7g inhibits angiotensin II-induced endothelial senescence via the LOX-1-independent mechanism. Int J Mol Med. Apr; 41(4): 2243-2251, 2018

  32. Chen CK, Hsu PY, Wang TM, Miao ZF, Lin RT, Juo SH*. TRPV4 activation contributes functional recovery from ischemic stroke via angiogenesis and neurogenesis. Mol Neurobiol May;55(5):4127-4135, 2018.

  33. Chen CK, Huang MH, Liang WL, Lin RT, Juo SH*. Early functional improvement after stroke correlates with cardiovascular fitness. Kaohsiung J Med Sci. 2018 Nov;34(11):643-649.

  34. Luh HT, Huang AP, Yang SH, Chen CM, Cho DY, Chen CC, Kuo LT, Li CH, Wang KC, Tseng WL, Hsing MT, Yang BS, Lai DM, Tsai JC. (2018 Jan) Local hemostatic matrix for endoscope-assisted removal of intracerebral hemorrhage is safe and effective. J Formos Med Assoc. 117(1):63-70.

  35. Chen CH, Huang HM, Chen DC, Wu CY, Lee HC, Cho DY*. (2018 Feb) Cortical bone trajectory screws fixation in lumbar adjacent segment disease: A technique note with case series. J Clin Neurosci. 48:224-228.

  36. Su CH, Li TC, Cho DY, Ma WF, Chang YS, Lee TH, Huang LC. (2018 May) Effectiveness of a computerised system of patient education in clinical practice: a longitudinal nested cohort study. BMJ Open. 8(5):e020621.

  37. Yang CA, Chou IC, Cho DY, Lin CY, Huang HY, Ho YC, Liu TY, Li YH, Chang JG. (2018 Aug) Whole exome sequencing in Dandy-Walker variant with intellectual disability reveals an activating CIP2A mutation as novel genetic cause. Neurogenetics. 19(3):157-163.

  38. Jan CI, Tsai WC, Harn HJ, Shyu WC, Liu MC, Lu HM, Chiu SC, Cho DY*. (2018 May) Predictors of response to autologous dendritic cell therapy in glioblastoma multiforme. Front Immunol. 9:727.

  39. Huang HM, Chen CH, Lee HC, Chuang HY, Chen DC, Chu YT, Cho DY*. (2018 Sep) Minimal invasive surgical technique in midline lumbar inter-body fusion: A technique note. J Clin Neurosci. 55:103-108.

  40. Jan CI, Tsai WC, Harn HJ, Shyu WC, Liu MC, Lu HM, Chiu SC*, Cho DY*. (2018 May) Predictors of response to autologous dendritic cell therapy in glioblastoma multiforme. Front Immunol. 9:727.

  41. Wen KC, Sung PL, Chou YT, Pan CM, Wang PH, Lee OK, Wu CW. (2018 Feb) The role of EpCAM in tumor progression and the clinical prognosis of endometrial carcinoma. Gynecol Oncol. 148(2):383-392.

  42. Fan JR, Lee HT, Lee W, Lin CH, Hsu CY, Hsieh CH and Shyu WC*. Potential role of CBX7 in regulating pluripotency of adult human pluripotent-like olfactory stem cells in stroke model. Cell Death and Disease 2018;9:502.

  43. Liu SP, Hsu YH, Huang CY, Ho MC, Cheng YC, Wen CH, Lu HE, Tsai CH, Shyu WC*, Hsieh CH. Generation of novel induced pluripotent stemcell (iPSC) line from a 16-year-old sialidosis patient with NEU-1 gene mutation. Stem Cell Research 2018;28,39–43.

  44. Chen-Chen Lee, Chu-Lun Lin, Sy-Jye Leu, Yueh-Lun Lee*. Overexpression of Notch ligand Delta-like-1 by dendritic cells enhances their immunoregulatory capacity and exerts antiallergic effects on Th2-mediated allergic asthma in mice. Clinical Immunology. 187:58-67; 2018.

  45. Chien-Hui Hung, Chien-Neng Wang, Huei-Hsuan Cheng, Jiunn-Wang Liao, Yi-Ting Chen, Ya-Wen Chao, Jia Liang Jiang, Chen-Chen Lee*. Baicalin Ameliorates Imiquimod-Induced Psoriasis-Like Inflammation in Mice. Planta Medica. 84(15):1110-1117; 2018.

  46. Chen YH*, Chung CC, Liu YC, Lai WC, Lin ZS, Chen TM, Li LY* and Hung MC*. YY1 and HDAC9c transcriptionally regulate p38-mediated mesenchymal stem cell differentiation into osteoblasts. Am J Cancer Res 8(3):514-525, 2018.

  47. Wang CT, Wang YY, Liu WS, Cheng CM, Chiu KH, Liu LL, Liu XZ, Wen ZH, Chen YH* and Chen TM. Rhodobacter sphaeroides Extract Lycogen™ Attenuates Testosterone-Induced Benign Prostate Hyperplasia in Rats. Int J Mol. Sci 19(4), 2018. (SCI, IF: 4.183).

  48. Lin ZS, Chung CC, Liu YC, Chen TM, Yu YL, Wang SC and Chen YH*. FOXA1 transcriptionally up-regulates cyclin B1 expression to enhance chondrosarcoma progression. Am J Cancer Res 8(10):1989-2004, 2018.