2019 年論文研究成果

  1. Lee, H.-H., Wang, Y.-N., Xia, W., Chen, C.-H., Rau, K.-M., Ye, L., Wei, Y., Chou, C.-K., Wang, S.-C., Yan, M., Tu, C.-Y., Hsia, T.-C., Chiang, S.-F., Chao, K.-S., Wistuba, II., Hsu, JL, Hortobagyi, GN, and Hung, M.-C. Removal of N-linked glycosylation enhances PD-L1 detection and predicts anti-PD-1/PD-L1 therapeutic efficacy. Cancer Cell, 36(2):168-178, 2019.
  2. Hu CM, Tien SC, Hsieh PK, Jeng YM, Chang MC, Chang YT, Chen YJ, Chen YJ, Lee EYP, Lee WH*, 2019, "High Glucose Triggers Nucleotide Imbalance through O-GlcNAcylation of Key Enzymes and Induces KRAS Mutation in Pancreatic Cells.", Cell Metabolism, 29(6), 1334-1349.e10.

  3. Li G, Gond JK, Liu J, Liu JZ, Li HH, Hsu AL*, Liu J*, Xu XZ*: Genetic and pharmacological interventions in the aging motor nervous system slow motor aging and extend lifespan in C. elegans. (2019) Science Advances. 5(1): eaau5041.

  4. Chan, L.-C., Li, C.-W., Xia, W., Hsu, J.-M., Lee, H.-H., Cha, J.-H., Wang, H.-L., Yang, W.-H., Yen, E.-Y., Chang, W.-C., Zha, Z., Lim, S.-O., Lai, Y.-J., Liu, C., Dong, Q., Yang, Y., Sun, L., Wei, Y., Nie, L., Hsu, J., Li, H., Ye, Q.,  Hassan, M.-M., Amin, H.-M., Kaseb, A.-O., Lin, X., Wang, S.-C., and Hung, M.-C. IL-6/JAK1 pathway drives PD-L1 Y112 phosphorylation to promote cancer immune evasion. Journal of Clinical Investigation, 15;129(8):3324-3338, 2019.

  5. WC-Shen, YC-Lai, LH-Li, Kolin Liao, HC-Lai, SY-Kao, John Wang, CM-Chuong, SC-Hung*. Methylation and PTEN activation in dental pulp mesenchymal stem cells promotes osteogenesis and reduces oncogenesis. Nature Communications, 10: 2226, 2019.

  6. CH-Liu, Sengupta Raj, CH-Chen, CT-Chou, IH-Chen, JT-Chien, IY-Lin, SY-Yang, Takashi Angata, WC-Tsai, James CC-Wei, IS-Tzeng, SC-Hung*, KI-Lin*. HLA-B-RARB-TNAP pathway promotes syndesmophyte formation in ankylosing spondylitis. JCI Minor revision.

  7. Jye-Lin Hsu*, Jen-Wei Chou, Tzu-Fan Chen, Fang-Yi Su, Joung-Liang Lan, Po-Chang Wu, Chun-Mei Hu, Eva Y‐HP Lee, and Wen-Hwa Lee* Glutathione peroxidase 8 negatively regulates caspase-4/11 to protect against colitis. EMBO Molecular Medicine Minor revision.

  8. HS-Hsu, CC-Liu, JH-Lin, TW-Hsu, JW-Hsu, Anna FY-Li, SC-Hung*. The essential role of collagen XVII-Oct4-HK2 in metabolic reprogramming of cancer stem cells. J. Biomedical Sciences minor revision

  9. CP-Tien, CH-Chen, WY-Lin, CS-Liu, KJ-Liu, Michael Hsiao, YC-Chang*, SC-Hung*. Ambient particulate matter attenuates sirtuin1 and augments SREBP1-PIR Axis to induce human pulmonary fibroblast Inflammation: Molecular mechanism of microenvironment associated with COPD. Aging, 2019. 11(13):4654-4671.

  10. KT-Chou, SC-Cheng*, SF-Huang, DW-Perng, SC-Chang, YM-Chen, HS-Hsu,  SC-Hung*. Impact of Intermittent Hypoxia on Sepsis Outcomes in a Murine Model. Sci Rep. Accepted

  11. ER-Chaing, HL-Ma, JP-Wang, MC-Chang, CL-Liu, TH-Chen, SC-Hung*. Use of Allogeneic Hypoxic Mesenchymal Stem Cells for Treating Disc Degeneration in Rabbits. J Orthop Res. 37: 1440-1450, 2019

  12. Vincent YF-Su, CS-Lin, SC-Hung, HY-Yang. Mesenchymal stem cell-conditioned medium induces neutrophil apoptosis associated with inhibition of the NF-κB pathway in endotoxin-induced acute lung injury. Int J of Mol Sci. 20:208, 2019.

  13. CH-Liu, HT-Chou, JW-Hsu, JH-Lin, TW-Hsu, David HT-Yen, SC-Hung*, HS-Hsu*. High metabolic rate and stem cell characteristics of esophageal cancer stem-like cells depend on the Hsp27-AKT-HK2 pathway. Int J of Cancer, 145(8):2144-2156, 2019.

  14. Peng HY, Chang MC, Hu CM, Yang HI, Lee WH, Chang YT*, 2019, "Thrombospondin-2 is a Highly Specific Diagnostic Marker and is Associated with Prognosis in Pancreatic Cancer.", Annals of Surgical Oncology, 26(3), 807-814.

  15. Li ST, Zhao HQ, Zhang P, Liang CY, Zhang YP, Hsu AL, Dong MQ: DAF-16 stabilizes the aging transcriptome and is activated in mid-aged C. elegans to cope with internal stress. (2019) Aging Cell. 18(3): e12896.

  16. Sural S, Lu TC, Jung SA, and Hsu AL*: HSB-1 inhibition and HSF-1 overexpression triggers overlapping transcriptional changes to promote longevity in C. elegans. (2019) G3-Genes Genomes Genetics, 9(5): 1679-1692.

  17. KH-Liao, VC-Wei, HL-Wang, HY-Chen, TW-Lai*. Carbogen inhalation opens the blood-brain barrier in rats without causing long-term metabolic or neurological deficit. Brain Research. 1720:146320, 2019.

  18. Kao, S.H., Cheng, W.C., Wang, Y.T., Yeh, H.Y., Chen, Y.J., Wu, H.T., Tsai, M.H. and Wu, K.J.* Concerted Regulation of miRNA Biogenesis and Histone Modification by K63-polyubiquitinated DDX17 Controls Cancer Stemness Features. Cancer Research, 79(10):2549-2563, 2019.

  19. Chen, S.H., Chow, J.M., Hsieh, Y.Y., Lin, C.Y., Hsu, K.W., Hsieh, W.S., Chi, W.M., Shabangu, B.M., and Lee, C.H. (2019) HDAC1,2 knock-out and HDACi induced cell apoptosis in imatinib-resistant K562 cells. Int. J. Mol. Sci., 20, 2271.

  20. Lin, C.L., Tsai, M.L., Lin, C.Y., Hsu, K.W., Hsieh, W.S., Chi, W.M., Huang, L.C., and Lee, C.H. (2019) HDAC1 and HDAC2 double knockout triggers cell apoptosis in advanced thyroid cancer. Int. J. Mol. Sci., 20, E454.

  21. Liu, L.-C., Wang, Y.-L., Lin, P.-L., Xiang Zhang, X., Cheng, W.-C., Liu, S.-H., Chen, C.-J., Hung, Y., Jan, C.-I., Chang, L.-C., Qi, X., Hsieh-Wilson, L.C., Wang, S.-C.* Long non-coding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15. International Journal of Cancer, 2019. (in press)

  22. Hung, Y., Liu, L.-C., Chen, C.-J., Wang, Y.-L., Lin, Y.-Z., Wu, W.-R., Wang, S.-C.* Long non-coding RNA HOTAIR in circulatory exosomes is correlated with ErbB2/HER2 positivity in breast cancer. The Breast,  46:64-69, 2019.

  23. Hung, Y., Wang, Y.-L., Lin, Y.-Z., Chiang, S.-F., Wu, W.-R., Wang, S.-C.* The exosomal compartment protects epidermal growth factor receptor from small molecule inhibitors. Biochemical and Biophysical Research Communications, 510: 42-47, 2019.

  24. Han, Y., Chen, M.-K., Wang, H,-L., Hsu, J.-L., Li, C.-W., Chu, Y.-Y., Liu, C.-X., Nie, L., Chan, L.-C., Yam, C., Wang, S.-C., He, G.-J., Hortobagyi, G.-N., Tan, X.-D., Hung, M.-C. Synergism of PARP inhibitor fluzoparib (HS10160) and MET inhibitor HS10241 in breast and ovarian cancer cells. American Journal of Cancer Research, 9:608-618, 2019.

  25. Su KJ, Yu YL*. Downregulation of SHIP2 by Hepatitis B Virus X Promotes the Metastasis and Chemoresistance of Hepatocellular Carcinoma through SKP2. Cancers (Basel) Jul 27;11(8), 2019.

  26. Wu TK, Wei CW, Pan YP, Hsu RJ, Wu CY and Yu YL*. The uremic toxin p-cresyl sulfate induces proliferation and migration of clear cell renal carcinoma via microRNA-21/HIF-1a axis signals. Sci Rep 9(1):3207, 2019.

  27. Wei CW#, Yu YL#, Lu JY, Hung YT, Liu HC and Yiang GT. Anti-Cancer Effects of Sulfasalazine and Vitamin E Succinate in MDA-MB 231 Triple-Negative Breast Cancer Cells. Int J Med Sci 16(4):494-500, 2019.

  28. Wei CW#, Yu YL#, Chen YH, Hung YT and Yiang GT. Anticancer effects of methotrexate with a-tocopherol and a-tocopherol succinate on triple-negative breast cancer. Oncol Rep 41(3):2060-2066, 2019.

  29. Liu H, Ertay A, Peng P, Li J, Liu D, Xiong H, Zou Y, Qiu H, Hancock D, Yuan X, Huang WC, Ewing RM, Downward J and Wang Y. SGLT1 is required for the survival of triple negative breast cancer cells via potentiation of EGFR activity. Mol Oncol 2019. Jun [Epub ahead of print]

  30. Wang M, Chao CC, Chen PC, Liu PI, Yang YC, Su CM, Huang WC and Tang CH. Thrombospondin enhances RANKL-dependent osteoclastogenesis and facilitates lung cancer bone metastasis. Biochem Pharmacol 166:23-32, 2019.

  31. Yang YC, Chiou PC, Chen PC, Liu PY, Huang WC, Chao CC and Tang CH. Melatonin reduces lung cancer stemness through inhibiting of PLC, ERK, p38, β-catenin, and Twist pathways. Environ Toxicol 34(2):203-209, 2019.

  32. Chen JY, Huang WC, Wei CT, Chien PH and Chen YJ. The C-Terminus of Hepatitis B Virus-encoded X Protein Is Required for Lapatinib Sensitivity in Hepatocellular Carcinoma Cells. Anticancer Res 39(2):721-726, 2019.

  33. Khan MI, Dowarha D, Katte R, Chou RH, Filipek A and Yu C*. Lysozyme as the anti-proliferative agent to block the interaction between S100A6 and the RAGE V domain. PLoS One 14(5):e0216427, 2019.

  34. Khan MI, Yuan T, Chou RH and Yu C*. S100A4 inhibits cell proliferation by interfering with the S100A1-RAGE V domain. PLoS One 14(2):e0212299, 2019.

  35. Chang KH, Hsu PY, Lin CH, Lin CL, Juo SH*, Liang CL*. Traffic-related air pollutants increase the risk for age-related macular degeneration. Journal of Investigative Medicine, 2019 Aug  [Epub ahead of print]

  36. Seow WJ, Ngo CS, Pan H, Barathi VA, Tompson SW, Whisenhunt KN, Vithana E, Chong YS, Juo SH, Hysi P, Young TL, Karnani N, Saw SM. In-utero epigenetic factors are associated with early-onset myopia in young children. PLoS One. 2019 May 17;14(5):e0214791.

  37. Hsi E, Wang YS, Huang CW, Yu ML, Juo SH*, Liang CL*. Genome-wide DNA hypermethylation and homocysteine increase a risk for myopia. Int J Opthalmol  12(1): 38-45, 2019.

  38. Cheng HY, Wang YS, Hsu PY, Chen CY, Liao YC, Juo SH* miR-195 has a potential to treat ischemic and hemorrhagic stroke through neurovascular protection and neurogenesis. Mol Ther: Methods Clin Dev Jan 7;13:121-132, 2019.

  39. Liang CL, Hsu PY, Ngo C, Seow WJ, Karnani N, Hong P, Saw SM, Juo SH*. HOXA9 is a novel myopia risk gene. BMC Opthalmol. Jan 23: 19(1):28, 2019.

  40. Chuang HY, Su YK, Liu HW, Chen CH, Chiu SC, Cho DY, Lin SZ, Chen YS, Lin CM. (2019 Jul) Preclinical Evidence of STAT3 Inhibitor Pacritinib Overcoming Temozolomide Resistance via Downregulating miR-21-Enriched Exosomes from M2 Glioblastoma-Associated Macrophages. J Clin Med. 2;8(7).

  41. Chiu SC, Chen KC, Hsia JY, Chuang CY, Wan CX, Wei TW, Huang YJ, Chen JM, Liao YA, Yu CR. (2019 Jul) Overexpression of Aurora-A bypasses cytokinesis through phosphorylation of SLAN. Am J Physiol Cell Physiol. doi: 10.1152/ajpcell.00032.2019. [Epub ahead of print]

  42. Liu LC, Wang YL, Lin PL, Zhang X, Cheng WC, Liu SH, Chen CJ, Hung Y, Jan CI, Chang LC, Qi X, Hsieh-Wilson LC, Wang SC. (2019 Apr) Long noncoding RNA HOTAIR promotes invasion of breast cancer cells through chondroitin sulfotransferase CHST15. Int J Cancer. doi: 10.1002/ijc.32319.

  43. Tsai FJ, Lai MT, Cheng J, Chao SC, Korla PK, Chen HJ, Lin CM, Tsai MH, Hua CH, Jan CI, Jinawath N, Wu CC, Chen CM, Kuo BY, Chen LW, Yang J, Hwang T, Sheu JJ. (2019 Jun) Novel K6-K14 keratin fusion enhances cancer stemness and aggressiveness in oral squamous cell carcinoma. Oncogene. 38(26):5113-5126.

  44. Hsieh SC, Lai CS, Chang CH, Yen JH, Huang SW, Feng CH, Chen YW, Li ZY. (2019 Jul) Nitric oxide: Is it the culprit for the continued expansion of keloids? Eur J Pharmacol. 5;854:282-288.

  45. Lee YH, Lee HT, Chen CL, ChangCH, Hsu CY, Shyu WC*. Role of FOXC1 in regulating APSCs self-renewal via STI-1/PrPC signaling. Theranostics 2019;9:22:6443-6465.

  46. PJ Pan , YC Liu, FT Hsu*. Protein Kinase B and Extracellular Signal-Regulated Kinase Inactivation is Associated with Regorafenib-Induced Inhibition of Osteosarcoma Progression In Vitro and In Vivo. Journal of Clinical Medicine 24;8(6), 2019.

  47. Chien-Neng Wang, Yu-Chao Lin, Bo-Chun Chang, Ching-Hsien Chen, Reen Wu, Chen-Chen Lee*. Targeting the phosphorylation site of MARCKS alleviates symptoms of steroid-resistant like asthma in a murine mode. British Journal of Pharmacology, 176(8):1122-1134; 2019.

  48. Yueh-Lun Lee, Ling-Heng Hsu, Yueh-Hsiung Kuo, Chen-Chen Lee*. Caffeic amide derivatives inhibit allergen-induced bone marrow-derived dendritic cells maturation. Pharmacological Reports. 71(2):194-200; 2019.

  49. Chen TM, Chen YH, Sun HS and Tsai SJ. Fibroblast growth factors: Potential novel targets for regenerative therapy of osteoarthritis. Chin J Physiol 62(1):2-10, 2019.

  50. Yang CJ, Kuo CT, Wu LH, Chen MC, Pangilinan CR, Phacharapiyangkul N, Liu W, Chen YH and Lee CH.   Eicosapentaenoic acids enhance chemosensitivity through connexin 43 upregulation in murine melanoma models. Int J Med Sci 16(5):636-643, 2019.